Days 1 & 2: Buenos Aires, Argentina

Day 3: Montevideo, Uruguay

Uruguay’s capital, Montevideo, often gets overshadowed by her larger, flashier sister across the Río de la Plata, Buenos Aires. While Montevideo may not have quite the bustle of Argentina’s capital, it shares that city’s cosmopolitan atmosphere and, of course, excellent steak houses. Its smaller size is also an advantage: There is a relaxed feel to this more low-key counterpart to BA.

Days 4 & 5: At Sea

Day 6: Stanley/Falkland Is/Islas Malvinas

The world's southernmost capital, Stanley is located in the Falklands archipelago, which consists of two main islands, East and West Falkland, along with smaller islands nearby. Stanley is proud of its British heritage, evidenced everywhere from its red telephone boxes to its pubs. The Falklands were first claimed by the English in 1765; over the centuries the Crown has had to abandon, reclaim and defend these far-flung islands from invading nations—including an Argentine foray in 1982. During the early years of their colonization, the Falklands were used as a base for ships hunting sperm whales for oil, followed by those hunting seals for fur. Today in this remote British territory, fishing and tourism are what drive the economy.

Day 7: Strait Of Magellan

Before the Panama Canal, there was the Strait of Magellan. This cinematic channel linking the Atlantic and Pacific oceans cuts between the mainland tip of South America and Tierra del Fuego island. It was the passage of choice for seafaring transport between these two oceans until the Panama Canal shortened the distance by thousands of miles in 1914.

Day 8: Punta Arenas, Chile, Cockburn Channel, Beagle Channel

If Punta Arenas exudes an "edge of the world" air, it's not without reason. This windblown city near Chile's southernmost tip sits on the Strait of Magellan, which itself is positioned squarely between the Atlantic and Pacific oceans. The city has played—and continues to play—an important role in geographic, political and economic affairs in South America's so-called Southern Cone, which is formed by Chile and neighboring Argentina. As you near the southern tip of South America, traveling along the Chilean or Pacific coast, you'll know that you're approaching the Cockburn (pronounced "CO-burn") Channel when you see the twin rocks that guard its entrance. The channel flows between the Brecknock Peninsula (the westernmost edge of Isla Grande de Tierra del Fuego) and a number of islands, including Clarence Island with its irregular coastline of dramatic sounds that reach deep into its interior. The channel is part of the route that connects the Strait of Magellan to the Beagle Channel, while along both sides of the waterway is one of the crown jewels of Chile’s network of parks: Alberto de Agostini National Park.

Day 9: Ushuaia, Argentina

Dramatic, fantastical, otherworldly—this is the end of the world, for real. Positioned at the southernmost tip of Argentina, this memorable port town is cradled between the pristine—and towering—Martial Mountains and accessed by the picturesque Beagle Channel (which was named for Darwin’s famed vessel). Ushuaia is the capital of the Tierra del Fuego region, which is best described as a spectacular collection of superlative natural wonders. It’s a veritable kaleidoscope of glittering glaciers, snowcapped mountains, dense forests, sparkling lakes and windswept plains spread across an archipelago of rugged islands.

Day 10: Scenic Cruising Cape Horn

It may be the most notorious ocean passage in the world, and for centuries it evoked dread in the hearts of sailors. But those who survived a trip around Cape Horn, where the Atlantic and Pacific slosh violently into each other, had bragging rights for life. Along this passage, the Tierra del Fuego, or "land of fire," where Chile and Argentina converge at the bottom of the world, got its name from early sailors who saw the fires of the people who lived here burning on shore. For some 8,000 years, until as recently as the end of the 19th century, this was the home of the Yaghan and other indigenous groups.

Day 11: Scenic Cruising Sarmiento Channel

One of the main channels in Patagonia, the Sarmiento Channel runs in a north-south direction, starting at the Guía Narrows and finishing at the southern edge of Victoria Pass, where it joins the Smyth Channel. The Kawesqar people have inhabited this region for more than 6,000 years, but the channel was named for a more recent arrival: the Spanish explorer Pedro Sarmiento de Gamboa, who first navigated it between 1579 and 1580. The Chilean mainland lies to the east, and the islands of Esperanza, Vancouver and Piazzi flank the channel to the west. As elsewhere in the Chilean fjord region, the ragged coastline is cut with inlets set among snow-covered mountain ranges. In many places, massive glaciers run down to the sea. All kinds of marine animals, including Magellanic penguins, southern elephant seals, dolphins and orcas, can be seen along these shores.

Day 12: Cruising Chilean Fjords

Much like the Norwegian coastline, the west coast of Chile is sliced by dramatic inlets, or fjords, lined with rugged mountains and glacier-covered valleys. This spectacular stretch of coastline starts near the Reloncaví Estuary (roughly halfway down the long spine of Chile) and extends south to the very end of the continent, at Tierra del Fuego. It's a distance of some 1,500 kilometers (930 miles), as the crow flies. Travel here, however, is never in a straight line—instead ships follow meandering paths along the many fjords and channels.

Day 13: Puerto Montt, Chile

Puerto Montt, the capital of the Los Lagos region of Chile, is often called the gateway to the country’s glacial lakes, volcanic landscapes and surrounding national parks. The port is also home to an over-100-year-old German settlement as well as to indigenous communities of Mapuche people. Adventure travelers often base themselves here and in Puerto Varas when planning treks to Chiloé and Patagonia. Even a short visit, however, provides a fascinating look into Chile’s diverse cultures and offers a taste of the country's stunning scenery.

Day 14: At Sea

Day 15: San Antonio (Santiago), Chile