Day 1: Fort Lauderdale, Florida, US

Days 2 & 3: At Sea

Day 4: Cartagena, Colombia

Its official name is Cartagena de Indias—or "Cartagena of the Indies"—but call it Cartagena for short. The formal name hints at this Colombian city's colonial relationship with Spain; it was founded in 1533 and named after the mother country's Cartagena. Colombia declared independence in 1810, but there's plenty about its fifth-largest city that evokes old Spain, including the impressive fort of Castillo San Felipe de Barajas, and the wall that encloses the old town, one of the few intact structures of its kind in the Americas. Both were considered important enough to inscribe on UNESCO's list of World Heritage Sites in 1984. They may be historical artifacts, but the fortress and wall aren't merely tourist attractions; they are central to daily life here. Take a stroll and you'll see couples sitting atop the wall, locked in passionate embraces; parents watching their children walk it like a balance beam; and friends chatting while enjoying the Caribbean breeze. Along with history, there's cultural and culinary intrigue here, too. This colorful city was a muse of the late Nobel Prize–winning writer Gabriel García Márquez, and is increasingly being recognized outside Colombia for its cuisine, which takes many cues from Caribbean ingredients. (Don't leave without trying the coconut rice.)

Day 5: Cruising Panama Canal

At the end of your journey along the Panama Canal, you’ll reach Balboa, the town that sits at the Pacific entrance of the canal. Its namesake is Vasco Núñez de Balboa, the famed Spanish explorer who was the first European to see the Pacific from the New World. Balboa’s journey was historic, a legendary feat of the age of exploration. The construction of the canal that crosses the isthmus today was also a historic achievement, to this day the largest civil engineering project ever. Over the course of a decade at the beginning of the 20th century, a combination of sheer human might and engineering prowess was responsible for the construction of the canal.

Day 6: At Sea

Day 7: Puerto Caldera (Puntarenas), Costa Rica

One of the stops along the Panama Canal Zone route, Puerto Caldera on Costa Rica's Pacific Coast isn't your ordinary port of call, positioned as it is within easy day-trip distance of the country's multiple national parks. The town itself is small, but makes for an ideal base from which travelers can venture out to explore the variety of this Central American country's outdoor attractions and activities. These include snapping photos of gushing waterfalls (and swimming at the base of one, if you bring your swimsuit!), sightseeing near active volcanoes, bird-watching in nature reserves and sanctuaries and horseback riding on Pacific beaches . . . and that's just for starters. Visitors to Puerto Caldera and the surrounding region also enjoy shopping for handicrafts that local artists sell at their cooperatives, as well as sampling traditional Tico cuisine, especially gallo pinto—a combination of rice and beans eaten at any time of the day or night. Puerto Caldera is the perfect reminder that adventure often awaits just around the bend.

Day 8: At Sea

Day 9: Puerto Quetzal, Guatemala

Puerto Quetzal is Guatemala's largest port on the Pacific Ocean side of this Central American country, important for both cargo and cruise ships. There's not a great deal to see and do in Puerto Quetzal itself, and visitors should adjust their expectations accordingly. Yet you shouldn't despair, either; Puerto Quetzal is an ideal point of departure for exploring several corners of the country. Choose your mode of transportation—plane, bus, car or boat—and decide whether you want to take in Guatemala's stunning, volcano-studded landscape, one (or more!) of the country's Maya sites, the UNESCO–recognized colonial city of Antigua (the former capital), a coffee plantation or one of the many beguiling bodies of water. In addition to the gleaming Pacific, there's Lake Atitlán, which 19th-century German explorer Alexander von Humboldt described as the most beautiful lake in the world. All of these attractions are accessible as day trips, and getting to them is all part of your Guatemalan adventure.

Day 10: Puerto Chiapas, Mexico

The southernmost port on Mexico’s Pacific coast, Puerto Chiapas is named for the state in which it is located. It is relatively new, built in 1975, and is the primary hub from which the region’s agricultural goods, including coffee, are sent abroad. For travelers arriving by cruise ship, the town of Puerto Chiapas is a jumping-off point to explore surrounding areas, including Tapachula, the second-largest city in the state of Chiapas. In addition to visiting the coffee estates and banana and cacao plantations of the area, day trips include excursions to Maya sites such as Izapa.

Day 11: Huatulco, Mexico

Huatulco, situated on Mexico's Pacific Coast in the state of Oaxaca, has nine bays and 36 beaches, offering more than enough opportunities for fun in the sun. The most popular beach is La Entrega, with clean white sand and calm waters, perfect for snorkeling and swimming . . . or just relaxing. But Huatulco's attractions aren't limited to sand and surf; there are also archaeological sites to explore, rivers to raft, and waterfalls whose pools invite childlike splashing. Bird lovers, in particular, will find Huatulco to be especially captivating.

Day 12: At Sea

Day 13: Puerto Vallarta, Mexico

Unique compared to Acapulco, Cancún, Zihuatanejo and several other coastal resort towns in Mexico—many of which were created by the government as planned communities—Puerto Vallarta ("PV" to locals), on the Pacific Ocean, retains quite a bit of its colonial-era charm. Its town square, Plaza de Armas, and the gorgeous parish church of Our Lady of Guadalupe, topped with an ornate crown and overlooking the port, serve as the loveliest representations of bygone ages. While on your Puerto Vallarta cruise, we take you alongside these echoes of the past are more modern attractions, including an ambitious public art project along the seaside walkway (the malecón) and trendy restaurants such as La Leche, serving contemporary Mexican cuisine.

Day 14: Cabo San Lucas, Mexico

Los Cabos doesn't exude the same kind of charm as many other areas of inland Mexico do, but its twin towns—San José del Cabo and Cabo San Lucas—don't seem to mind, and neither do visitors who take a cruise to Cabo, who are more or less drawn here less for traditional Mexican culture than for the sun, the sand and the opportunity to just slow down and relax. Los Cabos—or the Capes—sits at the southernmost tip of the Baja California Peninsula, a narrow strip of land whose varied geography, both above and underwater, makes for plenty of interesting activities and some unusual ones, too. Did you ever think you'd ride a camel in Mexico? You can do that here, or enjoy more predictable pursuits including fishing, golfing and whale-watching. Want something still more laid-back? On your Cabo cruise you can visit picture-perfect El Arco, an arch that may look familiar thanks to its cameo on postcards and tourism advertisements. North of the capes, you can drop by the famed Hotel California. And if you've worked up an appetite on your Cabo cruise, you won't be disappointed: Los Cabos offers plenty to enjoy at the table as well, with farm-fresh fruits and vegetables and, of course, seafood being the mainstays here. Regardless, Holland America Line makes sure that our Cabo cruises have plenty of new and traditional things for our guest to enjoy and experience.

Day 15: At Sea

Day 16: San Diego, California, US

Easygoing San Diego embodies the Southern California surfer town fantasy, with its more than 300 days of sun, mild year-round temperatures and accessible, sporty pastimes and tourist attractions. Cruise to San Diego and hike the Torrey Pines State Natural Reserve to get a glimpse of whale migrations, go sailing in the bay and, of course, surf the famous swells of Del Mar, Oceanside and La Jolla (among many other superb spots). Cruise from San Diego and explore the sixth-largest city in the United States. Discover San Diego’s distinctive neighborhoods on a San Diego shore excursion. Visit Old Town, North Park, Point Loma and Coronado are all within a few miles of the port, while the bustling Gaslamp Quarter and Little Italy are within walking distance.

Days 17 & 18: At Sea

Day 19: Victoria, British Columbia, Canada

A Victoria cruise delivers passengers to a charming British-influenced city plunked in the rugged Pacific Northwest. You can have high tea in an English garden and go whale watching the same day. Victoria ranks high for quality of life—you’re always a stone’s throw from a windswept beach or a pint at a convivial pub—and it’s the perfect swirl of city life and nature. The influence of the First Nations culture is also strong in Victoria, with totem poles taking a front-and-center position on the Inner Harbour and in Beacon Hill Park and extensive galleries devoted to the First People at the Royal Columbia Museum. A Victoria cruise means delicious dining is in store. Taste your way through Canada’s oldest Chinatown, sample fresh fish and chips, and gobble down heavenly Nanaimo bars.

Day 20: Vancouver, B.C., CA